- 주저자 : Choi SY, Kim YS(김영선), Seo YJ, Yang J, Choi KS
- 영문 제목 : Nanoparticles Composed of Gas-Filled Phospholipids Conjugated to Gadolinium Circulate for a Long Time and are a Potential Theragnostic for MR-guided High-intensity Focused Ultrasound Ablation
- 한글 제목 : 순환시간이 긴 가돌리늄 첨가 가스함유 인지질나노입자의 MR하이푸 치료시의 역할에 대한 실험연구
- 저널 : PLoS ONE
- 연도 : 2012
- 권 / 쪽 : 7 / 34333,1-10
- 초록 : To develop a long-circulating theragnostics, meaning therapeutics and diagnostics for MR-guided HIFU ablation, we designed and prepared Gd-C(5)F(12)-phospholipid nanobubbles (PLNs) 30-100 nm in diameter. The biochemical and physical characterization of Gd-C(5)F(12)-PLNs were performed. Since Gd-C(5)F(12)-PLN-50 (Φ = 50 nm) and Gd-C(5)F(12)-PLN-100 (Φ = 100 nm) enhanced the hyperthermal effect of HIFU size- and concentration-dependently in a tissue-mimicking phantom, its circulation, distribution, tumor accumulation and tumor ablation were examined in tumor-bearing mice. The plasma-half life of Gd-C(5)F(12)-PLNs was longer than 1.5 hrs. Gd-C(5)F(12)-PLNs mainly accumulated in the liver and the spleen, suggesting that they are slowly secreted through the hepatobiliary pathway. Monitored by the T1 signal intensity of MR, Gd-C(5)F(12)-PLNs accumulated in tumor tissues for 8 hours in mice. HIFU with Gd-C(5)F(12)-PLN-100 showed the increased tumor ablation area as compared with HIFU alone. The results suggest that Gd-C(5)F(12)-PLNs exhibit a potential theragnostics for MR-guided HIFU ablation.
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